Chief among those concerns are side effects, with 51% of respondents citing current side effects such as nausea, vomiting, headaches, and more as a top concern when it comes to GLP-1 medications, while 40% said they are worried about potential long-term side effects that may develop with use
And there are also obesity-related cancers, so Low Wang said it makes sense that if people control their diabetes and lose significant amounts of weight, their risks of getting cancer will also decline
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SURPASS-1 shows that tirzepatide alone, at all doses, was superior to placebo and revealed a dose-dependent reduction of HbA1c by up to 2.07% (p 10% weight loss can be disease modifying and may even lead to disease remission [38]
Yet by 2000, a strategy had emerged to prolong the effect of GLP-1 signaling: generate DPP-4 resistant peptides that bind and activate (i.e., agonize) GLP-1R
